How does the formation of nitrogen bubbles change with duration at altitude?

The formation of nitrogen bubbles increases with duration at altitude due to the principles of gas behavior under varying pressures. At higher altitudes, the atmospheric pressure is lower, which allows nitrogen, dissolved in the bloodstream and tissues, to come out of solution more readily as the body is exposed to this change in pressure.

When a person is at altitude for an extended period, the partial pressure of nitrogen decreases, which leads to nitrogen bubble formation. This is similar to what happens when a carbonated drink is opened, and the dissolved gases start to escape. The longer a person remains at altitude, the more nitrogen can come out of solution, potentially leading to an increased risk of decompression sickness.

Factors such as hydration, physical activity, and individual susceptibility can influence the exact amount of nitrogen bubbles formed, adding variability; however, in general terms, the risk and amount of nitrogen bubble formation rise with the duration at altitude.